B Cell Activation in HIV Infection

B Cell Activation in HIV Infection During HIV infection, B cells can be activated by HIV virions, plasmacytoid dendritic cells, infected macrophages and CD40 ligands. Mannose binding lectin (MBL), a C-type lectin, is in a complex with the MASP (MBL-associated serine proteases) enzyme and is involved in recognising and binding carbohydrates on pathogens (e.g. HIV envelope protein gp120 is highly glycosylated). When the carbohydrates are recognised, MBL activates the enzyme activity of MASP which causes the activation of the complement system by cleaving C2 and C4 complements resulting in the formation of C3 convertase. This activation and formation of C3 convertase is known as the alternative pathway of the complement system. C3 complement is cleaved by the C3 convertase enzyme and C3 fragments (C3d/C3dg, iC3b) are formed from this breakdown. These fragments are deposited onto the HIV virion surface. HIV IC (immune complexes) interact with CD21 (complement receptor) on B cells and C3 fragments acts as a mediator in the IC-CD21 interaction. CD21 is involved in the activation of B cells and a constant IC-CD21 activation could trigger the polyclonal a ctivation of B cells in HIV viremia. (1-4) Plasma dendritic cells (pDCs) express TLR9, TLR7, CD4, CCR5, CXCR4 and MCLR receptors. TLR7 receptor is stimulated by its interaction with viral ssRNA and TLR9 by its interaction with unmethylated DNA motifs of the viral genome. Stimulation of these receptors leads to the activation of intracellular pathways both of which involves the activation of the adaptor protein, MyD88. The MyD88-IRF7 pathway involves the activation of IRF7 by MyD88 which goes on to regulate the gene transcription of Type I IFN, leading to Type I IFN production by pDCs. NF-kB is also activated by MyD88 and causes the production of pro-inflammatory cytokines such as TNF-ÃŽ ± and IL-6 by upregulating their gene transcription in pDCs. IFN-ÃŽ ± (a Type l IFN) induces the activation and differentiation of B cells into plasmablasts. The presence of IL-6 causes differentiation of plasmablasts into antibody secreting plasma cells. TNF-ÃŽ ± is involved in the polyclonal activation of B cells. The production of Type I IFN upregulates the mRNA expression of two cytokines involved in stimulating B cells in pDCs. These cytokines cause the activation, proliferation and survival of B cells, immunoglobulin class- switching and are known as BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand). Both cytokines belong to the tumour necrosis factor (TNF) ligand family. BAFF interacts with B cells by binding to the BAFF receptor (BAFFR) located on the surface of B cells. Plasmacytoid dendritic cells also activate B cells through the interaction of their CD70 ligand with the CD27 receptor on B cells, causing proliferation and differentiation of memory cells into plasma cells. HIV infected macrophages, activate B cells by Nef protein indirectly when it is taken up and expressed de novo by infected macrophages. HIV Nef induces the production of ferritin through the NF-ÃŽ ºB pathway causing gene transcription and releasing ferritin from the infected macrophages. Adequate production of ferritin induces proliferation of resting B cells into antibody secreting plasma cells by upregulating the expression of B cell gene. This activation of B cells can lead to hypergammaglobulinemia the increase in the level of gamma globulins (immunoglobulins) in the blood. (1,20) Figure 1 shows adequate levels of ferritin can lead to increase in immunoglobulin (Ig) levels in the plasma (hypergammaglobulinemia). To determine whether there is a correlation between hypergammaglobulinemia (B cell dysfunction) and plasma ferritin level in HIV infection. Plasma Ig levels were compare to plasma ferritin levels of 83 infected HIV infected people. The results obtained show that there is a positive correlation between plasma ferritin levels and plasma levels of IgA, IgG and IgM in the HIV infected individuals studied. As plasma ferritin levels increased, plasma IgA, IgG and IgM levels also increased generally. (20) The outer layer (envelope) of HIV virions contains viral protein, gp120, which can directly bind to receptors on B cells. Activation of B cells by gp120 causes polyclonal immunoglobulin class switching. This occurs in the presence of BAFF which binds to its receptor on B cells, BAFFR and gp120 binds to MCLRs (mannose-binding C-type lectin receptors) on B cells. The interaction causes IgM to switch to IgG and IgA through the upregulation in the expression of the activation-induced cytidine deaminase, an enzyme involved in class-switch DNA recombination. The HIV gp120 has also been found to inhibit the production of IFN-ÃŽ ± by pDCs by affecting the activation of the TL9 pathway involved in its production. The protein, gp120 binds to CD4, CCR5, CRCR4 and MCLR receptors on pDCs and its binding to CD4 and MCLR has been found to not produce IFN-ÃŽ ± by the TLR9 pathway. This prevents the activation of B cells by the TLR9 pathway through the release of IFN-ÃŽ ±. (7,9,10,21) B cells can also be activated by the interaction between CD40 receptors on B cells and CD40 ligands on T cells in the presence of cytokines (e.g. IL-10). This interaction activates the B cells to differentiate and undergo immunoglobulin class switching by causing class-switch recombination. Class-switch recombination is induced by the activation of NF-kB transcription factor which induces the gene expression of activation-induced cytidine deaminase (AID). However, during HIV infection CD4+ T cells are targets for the HIV virus so number of CD4+ T cells are depleted suppressing this activation of B cells. (22,23) References: Moir, S., Malaspina, A., Li, Y., Chun, T., Lowe, T., Adelsberger, J., Baseler, M., Ehler, L., Liu, S., Davey Jr., R., Mican, J. and Fauci, A. (2000) ‘B Cells of HIV-1–infected Patients Bind Virions through CD21–Complement Interactions and Transmit Infectious Virus to Activated T Cells’, The Journal of Experimental Medicine, 192 (5), pp.637-645. Jakubik, J., Saifuddin, M., Takefman, D. and Spear, G. (2000) ‘Immune Complexes Containing Human Immunodeficiency Virus Type 1 Primary Isolates Bind to Lymphoid Tissue B Lymphocytes and Are Infectious for T Lymphocytes’, Journal Of Virology, 74(1), pp.552-555. Eisen, S., Dzwonek, A. and Klein, NJ. (2008) Mannose-binding lectin in HIV infection, Future Virol., 3(3), pp.225-233 Haurum , JS., Thiel, S., Jones, IM., Fischer, PB., Laursen, SB. and Jensenius, JC. (1993) ‘Complement activation upon binding of mannan-binding protein to HIV envelope glycoproteins.’, AIDS, 7(10), pp.1307-1313 Muraguchi, A., Hirano, T., Tang, B., Matsuda, T., Horii, Y, Nakajima, K. and Kishimoto, T. (1998) ‘ The Essential Role Of B Cell Stimulatory Factor 2 (Bsf-2/Il-6) For The Terminal Differentiation Of B Cells’, J Exp Med, 167, pp.332-344. Jego, G., Palucka, A., Blanck, J., Chalouni, C., Pascual, V. and Banchereau, J. (2003) ‘Plasmacytoid Dendritic Cells Induce Plasma Cell Differentiation through Type I Interferon and Interleukin 6’, Immunity, 19, pp.225-234. Chung, N., Matthews, K., Klasse, P., Sanders, R. and Moore, J. (2012) ‘HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells’, J Immunol, 189(11), pp. 5257- 5265. Shaw, J., Wang, Y., Ito, T., Arima, K. and Liu, Y. (2010) ‘Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70.’, Blood, 115, pp.3051–3057. He, B., Qiao, X., Klasse, P., Chiu, A., Chadburn, A., Knowles, D., Moore, J. and Cerutti, A. (2006) ‘HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors.’ J. Immunol, 176, pp.3931–3941. Martinelli, E., Cicala, C., Van Ryk, D., Goode, D., Macleod, K., Arthos, J. and Fauci, A. (2007) ‘HIV-1 gp120 inhibits TLR9-mediated activation and IFN-ÃŽ ± secretion in plasmacytoid dendritic cells.’ Proc Natl Acad Sci USA, 104, pp.3396–3401. Kadowaki, N., Ho, S., Antonenko, S., Malefyt, RW., Kastelein, RA., Bazan, F. and Liu, YJ. (2001) ‘Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.’, J Exp Med, 194 (6), pp.863-870 Lund, J., Sato, A., Akira, S., Medzhitov, R. and Iwasaki, A. (2003) ‘Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells.’, J Exp Med., 198 (3), pp. 513-520 Lund, JM., Alexopoulou, L., Sato, A., Karow, M., Adams, NC., Gale, NW., Iwasaki, A. and Flavell, RA. (2004) ‘Recognition of single-stranded RNA viruses by Toll-like receptor 7.’, Proc Natl Acad Sci USA, 101 (15), pp 5598-5603 Lambert, AA., Gilbert, C., Richard, M., Beaulieu, AD. and Tremblay, MJ. (2008) ‘The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis- infection pathways.’, Blood, 112(4), pp.1299-1307 Jego, G., Palucka, AK., Blanck, JP., Chalouni, C., Pascual, V. and Banchereau, J. (2003) ‘Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6.’, Immunity, 19(2), pp.225-234 Litinskiy, MB., Nardelli, B., Hilbert, DM., He, B., Schaffer, A., Casali, P. and Cerutti, A.(2002) ‘DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL.’, Nat Immunol., 3(9), pp. 822-829 Tezuka, H., Abe, Y., Asano, J., Sato, T., Liu, J., Iwata, M. and Ohteki T. (2011) ‘Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction.’, Immunity, 34(2), pp.247-257 Dai, J., Megjugorac, NJ., Amrute, SB. and Fitzgerald-Bocarsly, P. (2004) ‘Regulation of IFN regulatory factor-7 and IFN-alpha production by enveloped virus and lipopolysaccharide in human plasmacytoid dendritic cells.’, J Immunol., 173(3), pp.1535-48 Cerutti A., Qiao, X. and H, B. (2005) ‘Plasmacytoid dendritic cells and the regulation of immunoglobulin heavy chain class switching.’, Immunol Cell Biol., 83(5), pp.554-562 Swingler, S., Zhou, J., Swingler, C., Dauphin,A., Greenough, T., Jolicoeur, P. and Stevenson, M. (2008) ‘Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS’, Cell Host Microbe, 4(1), pp. 63-76. Geijtenbeek, TB., Kwon, DS., Torensma, R., van Vliet, SJ., van Duijnhoven, GC., Middel, J., Cornelissen, IL., Nottet, HS., KewalRamani, VN., Littman, DR., Figdor, CG. and van Kooyk ,Y. (2000) ‘DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.’, Cell, 100 (5), pp.587-597. Dedeoglu, F., Horwitz, B., Chaudhuri, J., Alt, FW. and S. Geha, RS. (2004) ‘Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkB.’, International Immunology, 16(3), pp.395-404 Qiao, X., He, B., Chiu, A., Knowles, DM., Chadburn, A. and Cerutti, A. (2006) ‘Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells.’, Nature Immunology, 7, pp.302-310 JESSIE FLORENCE GHANSAH

Democratic and Republican main constituencies and the current trends Essay

                 The two great political parties are one of the major political systems that were not envisaged by the founding for fathers. The two features that were constituted encompassed constitutional frameworks that encouraged the two party developments. The Electoral College, which was at least modified by the twelve amendments along with the single member district which, while not mandated constitutionally has been the rule rather than exception as from back 1970s. This tended to channel the politician into two major parties, each being incentivized to get majority backing and every party seeking to discipline factions as a coherent whole. The Republican and the Democratic parties are the oldest and also the third oldest political parties in the globe to date. The British conservative party, if dated from the Disraeli’s rebellion against Sir Peel Robert of the Corn Law in 1846 takes the second position of the oldest parties. (Alan, 2010).                   The Democratic Party can be dated since 1832, when the backers of incumbent president Jackson Andrew did organize a democratic national convention so as to nominate their hero for presidency along with his political manager Martin van Buren for the position of vice president. Since then, the democrats have met every four years period in unbroken string of 45 convections.                  The Republican political party was formed in the year 1854, either in Michigan, Ripon, Jackson or Wisconsin in opposition to what was termed as Kansas Nebraska act. The Republicans have met since 1856 every four years in national conventions. The Democrats and the Republicans constituencies                   These two political parties, since the ancient times have existed through the loyalty of constituencies. Without the aid of these constituencies, nothing at all can happen to boost them. These constituencies are the ones who vote and donate money to run these political parties. For instance, the democratic political party enjoys the following constituencies: the unionized labor, the ethnic minorities, the most women, the urban power blocks and the educated urbanites. These constituencies are the ones that contribute funds for this Democratic Party and give the votes to the flag bearers to ensure the perpetuity of the party. On the other hand, the Republican political party enjoys the following constituencies: the big businesses in the country, the massive corporations, almost all the defense related businesses, the small businesses, the health related businesses, the Christians, the National rifle association and the fundamentalists. It is very important to note that these groups are much generalized. Of course, not every woman or American- African guy will vote for the Democratic political party and not each and every business person will vote Republican. But these parties have allied themselves with the majority of the participants in these constituencies. In some of the instances, the political parties have been chosen by the constituencies instead of the other way round but the party policy and rhetoric speaks directly to these constituencies (Alan, 2010). Even if not always the fact, the parties wants to create the impression that they care about the interests of these groups. In Group and Out Group                     The main strength of the Republican Party is that their core constituencies are seen as undeniably and hence uniquely Americans or the natives. The main constituencies of the Republican Party is the people who are seen by other people or themselves or to put it in other words as the in group. In the 19th century, this in group mainly consisted of the Northern white Protestants. Today, this group mainly consist of the white married Christians and the most prosperous business people. The vital strength of the Republican Party constituencies is the composition of it of the uniquely and perhaps the undeniably American. The main weakness that this party has faced all through is that their core constituency has never been enough by itself to make the majority of the population of the Americans. America is seen by the outside world as being uniquely diverse country, but the fact is the US has been a diverse state always, ethnically, regionally, radically an d religiously. This regional diversity is the one that made Henry Adams to begin his American history in the Madison and Jefferson administration through a description of three main regional cultures that he segregated as: the South, Middle States and the New England. More diverse religiously, that the founders prohibited the nationally established churches. And also vowed not to interfere with any established churches in any state. More racially diverse that the 20 percent of the counted Americans in the first census of 1790 were the black slaves who are now the black Americans (Passelsand, 2002).                  On the other hand, the main constituency of the Democratic political party has always been the people who are seen by the outsiders and also by themselves as some people other than the ordinary Americans or in other words the outside groups. During the 19th century, these out groups constituted the White southern along with the urban Catholic of the immigrants’ origin and also the minor groups such as Mormons. Currently, these out groups includes, the highly educated seculars, the black Americans, and the single women and also the meager group of people that consist of Gays and lesbian (even though this is the only group that voted less democratic in 2008 than 2004) Current trends in the Republican and Democratic parties                  The major politics in America is changing rapidly and a very powerful demographic concatenation force is transforming the American electorates and also reshaping the main political parties. As the demographic transformation continues, the reshaping will always continue. The democratic political party will become more deepened to the constituencies that supported Barrack Obama in the his 2008 historic victory, and the republican party will be forced to dig hard into the center to compete for more constituencies.                     These trends are majorly being forced by the current activities that are taking place in the world, mainly the political aspect and the racial part of the concerned groups. For instance, the Iraq war that took place recently. This shifted the support of many Asian-American people to the Democratic Party. There is a widespread abandonment of the Republican Party by the Asian-Americans.                     According to the released data by the institute of politics at the Harvard university which was gathered from an online survey of 2525 18-24 year old, 47 percent of these youth currently identify themselves as democrats, 15% as republican and 39% as independent. This makes them more affiliated to the Democratic Party than any other ethnic group except the Africans. A Korean- American Betsy Kim, 44, sees a clear shift of the Asian American youth towards the Democratic Party. Kim says that the Asian –American of her age and younger lean to the Democratic Party due to the benefits that the party is doing to the communities of color (BEN, 2007).                  This is the pattern that is being repeated from constituency to the other and most of the states are moving towards the democratic direction. In the state of Pennsylvania, the white working class decreased by 25 points between the period 1`988 to 2008 while the white college students increased 16 points and also the minority by 8 points. In the Nevada city, the white who are the working class decreased by 24 points over this period and the minority voter up by 19 points with whiten college graduate by 4 points. These series of trends will continue and by 2040 the United States will be majority-Minority nation. So the Republican Party should seek more backing and restructure its politics so as to keep up with the ongoing trends. References Alan Berubeand others, (2010). State of metropolitan America. Washington: Brookinggs Institution. P. 50-63 Ben Adler 12/20/07Asian-American youth trend Democratic. PrintPasselsand Cohen, (2002). Us populations projections 2005-2050. Lopez and Minushkin. (2008). National latinos survey. Hispanic voter Attitudes Source document

Why Is the Aral Sea Shrinking

The Aral Sea is located between Kazakhstan and Uzbekistan and was once the fourth largest lake in the world. Scientists believe it was formed about 5.5 million years ago when geologic uplift prevented two rivers—Amu Darya and Syr Darya—from flowing to their final destinations.   The Aral Sea used to have an area of 26,300 sq miles and produce thousands of tons of fish for the local economy annually. But since the 1960s, it has been catastrophically shrinking. The Main Cause—Soviet Canals In the 1940s, the European USSR was going through a widespread drought and famine, and as a result, Stalin launched what is known as the Great Plan for the Transformation of Nature. Its purpose was to improve the overall agriculture of the country. The Soviet Union turned lands of the Uzbek SSR into cotton plantations—which operated on a system of forced labor—and ordered the construction of irrigation canals to provide water to the crops in the middle of the plateau of the region.   These hand-dug, irrigation canals moved water from the Anu Darya and Syr Darya rivers, the same rivers that fed the freshwater into the Aral Sea. Even though the irrigation wasnt very efficient and a lot of water leaked or evaporated in the process, the system of canals, rivers, and the Aral Sea were fairly stable until the 1960s.   However, in that same decade, the Soviet Union decided to expand the canal system and drain more water from the two rivers, suddenly draining the Aral Sea considerably. The Destruction of the Aral Sea Thus, in the 1960s, the Aral Sea began shrinking quite rapidly, with the lakes level dropping 20-35 inches yearly. By 1987, it dried up so much that instead of one lake, there were now two: the Large Aral (south) and the Small Aral (north).   While up to 1960, the water level was about 174 ft above sea level, it suddenly dropped to 89 ft in the Large Lake and 141 in the Small Lake. Yet, the world wasnt aware of this tragedy up until 1985; the Soviets kept the facts secret. In the 1990s, after gaining independence, Uzbekistan changed their way of exploiting the land, but their new cotton policy contributed to the further shrinkage of the Aral Sea. At the same time, the top and bottom waters of the lake were not mixing well, which caused the salinity levels to be highly uneven, thus allowing the water to evaporate from the lake even faster. As a result, in 2002, the southern lake shrunk and dried up to become an eastern lake and a western lake, and in 2014, the eastern lake completely evaporated and disappeared, leaving behind the desert called Aralkum, instead.   End of the Fishing Industry The Soviet Union was aware of some of the threats their economic decision posed to the Aral Sea and its region, but they regarded the cotton crops as far more valuable than the areas fishing economy. Soviet leaders also felt the Aral Sea was unneeded since the water that flowed in basically evaporated with nowhere to go. Prior to the evaporation of the lake, the Aral Sea produced about 20,000 to 40,000 tons of fish a year.  This was reduced to a low of 1,000 tons of fish a year at the height of the crisis. And today, instead of supplying food to the region, the shores have become ship graveyards, a curiosity for occasional travelers. If you happen to visit the former coastal towns and villages around the Aral Sea, youll be able to witness the long-abandoned piers, harbors, and boats. Restoring the Northern Aral Sea In 1991, the Soviet Union was disbanded, and Uzbekistan and Kazakhstan became the new official homes to the vanishing Aral Sea. Since then, Kazakhstan, along with UNESCO and a multitude of other organizations, have been working to resuscitate  the Aral Sea. Kok-Aral Dam The first innovation that helped save part of the Aral Sea fishing industry was Kazakhstans construction of the Kok-Aral Dam on the southern shore of the northern lake, thanks to support from the World Bank. Since the end of its construction in 2005, this dam has helped the northern lake to grow. Before its construction, the sea was 62 miles away from Aralsk, a port city, but it started growing back, and in 2015 the sea was only 7.5 miles away from the port town. Other Initiatives The second innovation has been the construction of the Komushbosh Fish Hatchery at the northern lake where they raise and stock the northern Aral Sea with  sturgeon, carp, and flounder. The hatchery was built with a grant from Israel.   Predictions are that thanks to those two major innovations, the northern lake of the Aral Sea could produce  10,000 to 12,000 tons a fish a year. Low Hopes for the Western Sea However, with the damming of the northern lake in 2005, the fate of the southern two lakes was nearly sealed and the autonomous northern Uzbek region of  Karakalpakstan will continue to suffer as the western lake continues to vanish.   Nonetheless, cotton still continues to be grown in Uzbekistan. As if following in the old USSR traditions, the country comes near a standstill during the harvest season, and almost every citizen is forced to volunteer each year.   Environmental and Human Catastrophe Besides the sad fact that the Aral Sea has been disappearing, its huge, dried-up lakebed is also a source of disease-causing dust that blows throughout the region.   The dried remnants of the lake contain not only salt and minerals but also pesticides like DDT that were once used in huge quantities by the Soviet Union (ironically, to make up for the lack of water). Additionally, the USSR once had a biological-weapons testing facility on one of the lakes within the Aral Sea.  Although now closed, the chemicals used at the facility help to make the destruction of the Aral Sea one of the great environmental  catastrophes  of human history. As a result, the entire ecosystem is affected, and it will take years to restore. Few crops grow in this region, furthering the use of pesticides and contributing to the vicious cycle. The fishing industry, as mentioned, has almost completely disappeared, also affecting other animals that used to live in this location. On a human level, because of the poor economy, people were forced into heavy poverty or they had to move. Toxins are present in the drinking water and have entered the food chain. Coupled with the scarcity of resources, this puts at risk the most vulnerable groups, and women and children of the region tend to suffer from many diseases. However, in 2000, UNESCO published a Water-Related Vision for the Aral Sea Basin for the Year 2025. It is considered to be the basis for positive actions that would lead to securing a bright and sustainable future for the Aral Sea region. With the other positive developments, there is perhaps hope for this unusual lake and the life dependent on it. Sources â€Å"UNESCO Launches New Aral Sea Basin Initiative.†Ã‚  UNESCO.Micklin, Philip, and Nikolay V. Aladin. â€Å"Reclaiming the Aral Sea.†Ã‚  Scientific American, vol. 298, no. 4, 2008, pp. 64–71.â€Å"Kazakhstan: Measuring the Northern Aral.†Ã‚  Stephenmbland, 2015.Greenberg, Ilan. â€Å"As a Sea Rises, So Do Hopes for Fish, Jobs, and Riches.†Ã‚  The New York Times, The New York Times, 6 Apr. 2006.â€Å"Water-Related Vision for the Aral Sea Basin for the Year 2025.†Ã‚  Unesdoc.unesco.org, UNESCO, Imprimerie Des Presses Universitaires De France, 2000.

The Impact of the New Deal on the Great Depression Era Essay

The Impact of the New Deal on the Great Depression Era In 1933, President Roosevelt proposed New Deal legislation to alleviate the effects of the Great Depression through various public works programs and other federal initiatives. The many reforms of the New Deal were racked by intense criticism from their very beginnings. The New Deal was a catalyst in the surge of the federal government’s power. One year before the financial collapse on Wall Street, President Hoover said, â€Å"We in America today are nearer to the financial triumph over poverty than ever before in the history of our land† (Major 31). This overly confident statement was outrageously wrong. On October 24, 1929, the Wall Street stock market plummeted. As of that date,†¦show more content†¦15). The FERA’s main purpose was to assume economic responsibility for 18 million unemployed Americans. FERA was to help these people find work through the private sector. FERA was intended to allow unemployed people regain their dignity and improve their economic status (Hopkins par. 12). Many people outside of the United States foresaw the greatness and legacy that would follow the Roosevelt administration. For instance, Neville Chamberlain, the British Chancellor of the Exchequer (later to become the British Prime Minister), said before the House of Commons concerning FDR’s first 100 days in office â€Å"Within weeks of taking office Roosevelt had carried off his first triumph, the restoration of national confidence† (Rosenman 66). Key factors of New Deal reforms to end the depression were to create work relief programs. The epitome of F.D.R.’s feelings toward work relief were spoken eloquently when he said â€Å"The test of our progress is not whether we add more to the abundance of those have it much; it is whether we provide enough for those who have too little† (Wolters 170). 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At the same time, the financial crisis destroyed the life savings of countless Americans (Modern American Poetry). Food, housing and other consumable goods were in short supply for most people (Zinn 282). This widespreadRead MoreImpact Of The New Deal On The Great Depression1355 Words   |  6 Pages Impact of the New Deal on the Great Depression Preceding the Great Depression, the United States went through a glorious age of prosperity, with a booming market, social changes, and urbanization; America was changing. At the end of the 1920’s and well through the 1930’s, America was faced with its greatest challenge yet; the 1929 stock market crash. It would be the end of the prosperity of the â€Å"Roaring Twenties†. Now the American government and its citizens were faced with a failing economyRead MoreWomen s Role During The Great Depression1232 Words   |  5 PagesAs the Great Depression crept up on the United States people began to see the effects of the economic down spiral. To try a keep afloat people did what they could to survive. The role women played during this time period was a strong example of this drive for survival. Women stepped up to the plate for their family and jumped into the workforce to become the new breadwinners of their family. They broke barriers and didn t care what people thou ght of them. Even though most of the jobs out there wereRead MoreEssay on The Great Depression and The New Deal 1211 Words   |  5 PagesThe Great Depression and The New Deal The Great Depression first started as early as 1928, but did not affect the United States until 1929. The Great Stock Market crash started the event of the Depression here in America, but was not the main cause to why it happened. During the early stages of the depression, President Hoover failed to help the economy and continuedRead MoreThe Constitutional Right Of Liberty Of Contract, By Franklin D. Roosevelt And His New Deal1494 Words   |  6 Pagesthe other side of things are the beliefs of the Democrats, their views in favor equal opportunity for the working class. Through time Liberal President, Franklin D. Roosevelt and his â€Å"New Deal† as well as Conservative Republican Ronald Regan and his â€Å"Trickle Down Economics†, have both made the biggest economic impacts regarding the debate. The constitutional right of liberty of contract, mandated by the Supreme Court in the early 20th century, is allowing government to be involved with businesses